Stem Cell Treatment for Rheumatoid Arthritis

Stem Cell Treatment for Rheumatoid Arthritis

What is Rheumatoid Arthritis?

Rheumatoid Arthritis (RA) is an autoimmune disorder where the individual’s immune system creates cellular and antibody responses to several elements of the joint like type I collagen. As a consequence of this immune reaction, not merely does joint destruction happen, but also other secondary complications like pulmonary fibrosis, renal impairment, and sometimes even heart damage.

Could stem cells help cure rheumatoid arthritis?

Recently diagnosed rheumatoid arthritis is presently treated with immune suppressive agents such as steroids, methotrexate, cyclosporine, golden, and much more lately infliximab (Remicade). Despite causing temporary development, these methods have long-term negative effects because of non-specific inhibition of immune reactions. When disease-modifying anti-rheumatic drugs (DMARDs) such as methotrexate aren’t successful, biologics such as abatacept (Orencia), adalimumab (Humira) or etanercept (Enbrel) could be recommended. None of those treatments tackle the problem of harm that has already happened to the joints or extra-articular tissues.

Though improvements in rheumatoid arthritis (RA) therapy protocols and the introduction of targeted herbal treatments have improved patient outcomes up to 50 percent of patients still don’t accomplish a substantial clinical reaction.

Stem cell treatment was proven to induce deep recovery activity in animals with several kinds of arthritis. By way of instance, Tomorrow Doctor routinely uses stem cells with different joint deformities to hasten recovery. Besides recovery of damaged cells, stem cells have the exceptional capability to regulate the immune system in order to shut off pathological reactions while maintaining the ability to fight disease.

Stem cells and especially, mesenchymal stem cells (MSCs) homes to inflamed tissue and begin generating anti-inflammatory agents. All these mediators act locally and don’t suppress the immune reaction of the individual’s body. Furthermore, MSCs induce the creation of T regulatory cells, a kind of immune cell whose role is to guard the body from immunological self-attack.

A recent analysis on MSCs for rheumatoid arthritis (Human Umbilical Cord Mesenchymal Stem Cell Therapy for Patients with Active RA: Safety and Efficacy) revealed that MSCs generated a substantial reduction in pro-inflammatory cytokines IL-6 and TNF-α, both which are targeted by several present RA remedies. — Without the long-term unwanted effects.

Through administration of umbilical cord tissue-derived mesenchymal stem cells, we’ve observed improvements in rheumatoid arthritis patients treated in our centers .

Which kinds of stem cells have been utilized to treat rheumatoid arthritis and how are they collected?

The stem cells used as a treatment for RA in the Tomorrow Doctor Institute come from human umbilical cord tissue (allogeneic mesenchymal).

The mesenchymal stem cells we use are retrieved from donated umbilical cords after ordinary, healthy births. Every mommy has her medical background screened and can be analyzed for infectious diseases. Approval is obtained from every family before donation. All umbilical cord-derived stem cells have been screened for infectious diseases to International Blood Bank Standards until they are cleared to be used in patients.

Just a small fraction of donated umbilical cords pass our rigorous screening procedure. Considering that HUCT mesenchymal stem cells are immune system , mobile rejection is no problem and Human Leukocyte Antigen (HLA) matching isn’t crucial. The stem cells together with the very best anti-inflammatory action, immune regulating capability, and capacity to stimulate regeneration could be screened and chosen.

Allogeneic stem cells could be administered multiple times within the duration of times in uniform doses which feature high cell counts. Umbilical cord tissue supplies an abundant source of mesenchymal stem cells. It’s not necessary to collect stem cells from the patient’s hip bone or fat under anesthesia, which notably for smaller children and their parents, may be an unpleasant ordeal.

There’s an increasing body of evidence demonstrating that tubal cord-derived mesenchymal stem cells are somewhat more powerful than mesenchymal stem cells from different sources. It’s not necessary to administer chemotherapy medications such as Granulocyte-colony stimulating factor (G-CSF or GCSF) to stimulate the bone marrow to create granulocytes and stem cells and then discharge them in the blood vessels.

Our mesenchymal stem cells along with the US FDA: Why are they accepted?

Human umbilical cord tissue-derived mesenchymal stem cells (MSCs) which were isolated and developed in our lab to make master cell banks are now being used under the US FDA regulations.

These cells function as the starting material for mobile products utilized in MSC clinical trials for 2 Duchenne’s muscular dystrophy patients under US FDA’s designation of Investigational New Drug (IND) for single individual compassionate use. (IND 16026 DMD Single Patient).

Can the individual refuse this kind of stem cell?

The human body’s immune system is not able to comprehend tubal cord-derived mesenchymal stem cells as foreign and so they aren’t rejected. HUCT stem cells are administered thousands of times in the Tomorrow Doctor Institute and there’s never been one case rejection (graft vs. host disease). As a matter of fact, allogeneic (not the individual’s personal ) mesenchymal stem cells have been accepted to take care of graft vs. host disease in Canada and New Zealand.

Umbilical cord-derived mesenchymal stem cells additionally proliferate/differentiate more effectively than “elderly” cells, like those found at the fat and so, they are regarded as more “potent”.

Are the stem cells handled for rheumatoid arthritis therapy?

They’re generally given intravenously (IV) over the span of a couple of days.

Stem Cell Therapy: Allergic Arthritis Protocols

Treatment protocol will likely be delegated by staff doctors after the individual has filed all requested medical advice and obtained consent.

Can someone out of the Tomorrow Doctor Institute be following up with me once I return home?
Our health care team will be calling you in regular intervals to determine how you’re doing. Periodic follow-up helps us assess general treatment efficiency. Thus, our medical team will follow up with you after 1 month, 3 months, 6 months, and one year.

How do I request more info?

You will contact us by phone 1 (661) 836 2226

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Dr. Curt Collins